Keynote and Invited Speakers
Keynote Speaker
Prof. Tjokorda Gde Tirta Nindhia
Udayana University, Indonesia
Tjokorda Gde Tirta Nindhia received Doctor Degree from Gadjah Mada University (UGM) Yogyakarta, Indonesia on August 2003, with major field of study was Material Engineering. He participated in various international research collaborations such as with Muroran Institute of Technology Japan (2004), Toyohashi University of Technology Japan (2006), Leoben Mining University Austria (2008-2009), Technical University of Vienna Austria (2010), Institute Chemical technology of Prague Czech Republic (2012-now) and very recently with Michigan State University (MSU) and University of Hawaii in the USA under Fulbright Scholarship. His current job is as Full Professor in the field of Material Engineering at Engineering Faculty, Udayana University, Jimbaran, Bali, Indonesia. His research interest covers subjects such as, Biomedical Engineering, biosensor, biomaterial, waste recycle, failure analyses, advance ceramic, metallurgy, composite, renewable energy, and environmental friendly manufacturing.
Speech Title: "Biocompatibility and Tensile Strength of Natural Silk Fibers: Bombyx mori, Cricula trifenestrata and Attacus atlas"
Abstract: Three types of silk fiber obtained from silkworm cocoon from 3 diferent species of silkworm cocoon namely: Bombix mory, Cricula trifenestrata and Attacus atlas were investigated in this research. The biocompatibility and tensile strength will be investigate and compared for future consideration in application as biomaterial. Bombyx mori silk is well known and obtained from domesticated silkworm cocoon of Bombyx mori. It is biocompatible as biomaterial and has been used commercially as sutures in biomedical. Bombyx mori silkworm eat only one (monophagous) type of leaf (leaf of mulberry plant). Both Cricula trifenestrata and Attacus atlas are wild silkmoth and fiber can be obtained from its cocoon. Cricula trifenestrata and Attacus atlas are wild (non domesticated) and eat variety of leaf plant in their development. It can be concluded that the silk obtained from cocoon of Cricula trifenestrata has best biocompatibility properties followed by Attacus atlas and after that Bombyx mori. The highest tensile test is found for Bombix mori (230 MPa) followed by Attacus atlas (101 MPa) and the lowest is Cricula trifenestrata (162 MPa).
Keynote Speaker
Assoc. Prof. Keimei Oh
Akita Prefectural University, Japan
Dr. Keimei Oh was born in Shanghai, China. He received B.Sc. in the Department of Chemistry from Shanghai University and Ph.D. degree from the Graduate School of Agricultural and Life Sciences, The University of Tokyo in 1997. After working at RIKEN as a Special Postdoctoral Fellow, he joined the Department of Biotechnology faculty at Akita Prefectural University in 1999. In 2003, he worked as a visiting scientist at US Department of Energy, Plant Research Laboratory in Michigan State University. He was appointed as Associate Professor at Akita Prefectural University in 2007. Currently, he is working in the field of design and synthesis biological active chemicals targeting plant hormone biosynthesis and signaling transduction pathways. He received numerous awards including the Society Award of the Japanese Society for Chemical Regulation of Plants.
Speech Title: "A Chemical Genetics Strategy That Identifies Small Molecules Which Induce the Triple Response in Arabidopsis"
Abstract:
Chemical genetics is an effective way to discover new
biological active compounds. The process is based on the
phenotypic screening of compound libraries through searching
chemicals that are able to induce phenotypes of interests.
In the present study, report the discovery of new compound
that induce “triple response” in Arabidopsis Among
9600 compound, we found a compound with pyrazole moiety
(EH-1) exhibited promising activity to induce triple
response in Arabidopsis seeding. To determine the
action mechanism of EH-1, insensitive mutants of ethylene
signaling were used. Also, we carried out RNA sequencing
(RNA-seq) analysis.
Acknowledgement: This research is supported by JSPS KAKENHI
Grant Number 16K01936 to Keimei Oh and is partially
supported by the Platform Project for Supporting in Drug
Discovery and Life Science Research（Platform for Drug
Discovery, Informatics, and Structural Life Science）from
Japan Agency for Medical Research and Development (AMED).
Invited Speaker
Assoc. Prof. Yusnita Rifai
Hasanuddin University, Indonesia
Yusnita Rifai has received master degree in Faculty of Medicine Flinders University (Australia) and then graduated with doctoral degree from Chiba University (Japan). She was honored of Endeavour Post-Doctoral Fellowship 2014 to continue her post-doctoral study at the University of Newcastle Australia. Her research interests lie in the area of drug discovery, including drug synthesis. There are some of research in medicinal chemistry that obtained recognitions, one of them is from Timmerman Award in 2003. For her new research, she succeeds to receive recognition from National L’Oréal For Woman in Science Fellowship 2013. She had published several international journals while delivering her presentation in various annual meeting of Pharmaceutical Society in the related field. She gained recognition from Grant Sinas Incentive from The Ministry of Research and Technology of Republic of Indonesia (2012-2013), Grant Drug Discovery from the Ministry of Health Republic of Indonesia (2014), Grant Ipteks and Competence from Ministry of Research and Technology of Republic of Indonesia (2016-2018).
Speech Title: "Direct Binding Site Studies of Glioma Receptors on Lignan, Flavonoid and Alkaloid Constituents"
Abstract: Glioma (GLI) has been considered as a promising target for selective cancer therapy. We selected plants with known anticancer activity and performed in silico screening with 27 alkaloids, 28 lignans and 23 flavonoids against 2GLI as a target. The docking protocols used PLANTS (Protein-Ligand Ant System) software and evaluated parameters were included the interaction energy and hydrogen bond. A crystal structure of cyclopamine binds to 2GLI was used as the reference structure at the score of root mean square deviation of 1.614 Ǻ. In this study, molecules with the lowest scores indicate the good stability affinity. Evodiamine, saurosporinone, 4-ketopinoresinol, taxiresinol and xanthohumol have a PLANTS® score which close to cyclopamine in both aqueous and non-aqueous environments. Therefore, these compounds are predicted in silico having an affinity identical to the affinity of cyclopamine to the GLI Protein.
Keynote Speaker
Prof. Robert Borris
Tianjin University, China
Following completion of a BS degree (Biology) from Loyola University in Chicago, Robert P. Borris earned his BS (Pharmacy) and PhD (Pharmacognosy) degrees at the University of Illinois Medical Center in Chicago. He then pursued postdoctoral studies in organic chemistry at the University of Zurich (Switzerland). Returning to the United States, he served as an Assistant Professor of Pharmacognosy at Rutgers University before moving to the pharmaceutical industry where he established and headed phytochemical research in the New Drug Discovery programs at Merck Research Laboratories. Retiring after a long career at Merck, he became Vice President for Botanical Science and Regulation at the Council for Responsible Nutrition (Washington DC) before moving to the University of Hawaii at Hilo as Associate Dean for Research at the newly formed Daniel K. Inouye College of Pharmacy. After seven years in Hawaii, he moved to his current position of Professor and Vice Dean (Research and Academic Programs) at the School of Pharmaceutical Science and Technology, Health Sciences Platform, at Tianjin University. Throughout his career, his passion for “Discovery” in general and “Natural Products Chemistry” in particular have enabled him to become President of the American Society of Pharmacognosy (1997-8) and a Fellow of the Linnean Society of London. Research in the Borris Laboratory focuses on the isolation and structure elucidation of naturally occurring compounds with biological activity and/or taxonomic significance, including the general theme of exploring the disconnect between traditional medicine and Western medical science.
Speech Title: "Back to the Future: Exploring the Disconnect Between Traditional Chinese Medicine and Western Medical Science"
Abstract: The World Health Organization (WHO) has stated that the majority of people worldwide rely on some form of traditional medicine to address their medical needs. Some of these traditional practices, including Traditional Chinese Medicine (TCM) for example, have been used, documented and refined over the space of thousands of years. Efficacy is well documented and often undeniable. Nonetheless, many published and unpublished investigations in Western laboratories have failed to detect and/or isolate the chemical principles that are responsible for the observed biological activities in man. The inability of Western science to ‘validate’ the efficacy of TCM in the laboratory has contributed to the skepticism about traditional medicine that is prevalent throughout much of the “Developed World”, severely limiting the acceptance of TCM outside of China. The present study explores some potential reasons for the apparent disconnect between the observed clinical efficacy of TCM and the disappointing results in laboratory studies.
Invited Speaker
Assoc. Prof. Bappaditya Chatterjee
International Islamic University Malaysia, Malaysia
Bappaditya Chatterjee did his Ph.D degree in Pharmacy from Jadavpur University, India. After few years of industrial experience in Fresenius Kabi Oncology Ltd (Germany based multinational anti-cancer drug manufacturer), he joined Department of Pharmaceutical Technology, International Islamic University Malaysia (IIUM) as an Assistant professor. Presently he is working in the same university as an Associate Professor. In his total 8 years of research carrier, Dr Bappaditya has published more than 40 scientific articles in reputed international journal on formulation development with synthetic drugs and analytical method development-validation. He has presented his research papers in 16 international conferences and secured three best presenter awards. In the year of 2018, he was awarded with “Promising researcher” award by IIUM. Dr. Bappaditya has secured eight research projects on pharmaceutical formulation development out of which five have been funded by the Government of Malaysia. His most recent research project is on nose to brain targeted drug delivery system. Apart from this, filling of 3 patents, supervising 11 post graduate students, industrial consultancy are few of his professional activities. His research interest is formulation development and drug delivery system for poor soluble synthetic drug candidates based on amorphous solid dispersion or nano-emulsion, transfersomes etc.
Speech Title: "Intra Nasal Drug Delivery Targeting Brain"
Abstract: Blood brain barrier (BBB), is the major challenge for a drug, especially large molecule or water soluble drugs, to reach the brain after oral delivery. It requires either high dose and invasive drug delivery or modified formulation. Drugs delivered by intra-nasal route have high possibility of reaching the brain bypassing BBB, thereby minimizing doses and chances of systemic adverse effect. Two different formulations were developed, containing pregabalin and sumatriptan, two drugs preferably act on the nervous system, to deliver via intra –nasal route. Pregabalin was formulated as pH sensitive intra-nasal gel and sumatriptan as nanoemulgel. Ex-vivo permeation test using goat nasal mucosa showed excellent drug permeation for both of the formulations. In-vivo study on rat model, was done to evaluate the brain distribution efficiency with comparison to oral administration. Pregablin and sumatriptan showed 1.32 times and 1.58 times higher drug availability in brain, respectively. It could be assumed that enhancement of drug retention time on nasal mucosa and absorption via olfactory pathway increased drug concentration in the brain. Stability study and mechanistic investigation on pathway of absorption is in the future plan. The researchers acknowledge the support of the Ministry of Higher Education, Malaysia (FRGS 17-006-0572) for the work.